Important dates
Deadline for abstract submission is May 10th, 2022.
Deadline for late breaking abstracts is July 31st, 2022.
Registration early bird deadline July 1st, 2022.
Notification of abstract acceptance and presentation type (oral/poster/late breaking) July 2022.
Program
Detailed program August 24th Click here
Please note there will not be any hard copy and you should print the program in advance if you wish to bring it to conference.The registration desk is located in Fabrikstrasse 6, during the conference. Coffee and lunch breaks will be served in Fabrikstrasse 8.
Teaching day Click here
Provisional abstract book Click here Please note that the abstract book is only available online – not as hardcopy.
Molecular Immunology version Click here
Late breaking posters Click here
Friday, August 26, 2022 (08:30-14:45)
Teaching Day followed by a welcome reception at 18:00.
Excursion at 15:00 for 2 hours.
Part 1: Overview lectures – Auditorium 001, Building Fab6 .
These lectures are open to everyone, no special registration needed
08.30 – 09.00 Coffee & croissants
09.00 –
09.05
WELCOME AND INTRODUCTION
Daniel Ricklin, Verena Schroeder
09.05 –
09.25
OVERVIEW OF THE COMPLEMENT SYSTEM AND ITS CANONICAL ROLES
IN HOST DEFENSE AND HOMEOSTASIS
Tom Mollnes
09.25 –
09.45
NON-CANONICAL COMPLEMENT FUNCTIONS AND CROSSTALK WITH
OTHER DEFENSE SYSTEMS
Leendert Trouw
09.45 –
10.05
COMPLOTYPE & COMPLEMENTOPATHIES: COMPLEMENT AS LONGTERM DISEASE CONTRIBUTOR
Claire Harris
10.05 –
10.25
COMPLEMENT IN ACUTE-PHASE DISORDERS WITH A FOCUS ON BACTERIAL INFECTIONS AND SEPSIS
Suzan Rooijakkers
10.25 – 10.45 COMPLEMENT AS TARGET FOR THERAPEUTIC INTERVENTION Daniel Ricklin
10.45 –
11.00
PRESENTATION OF ECCO (EARLY-CAREER COMPLEMENTOLOGISTS)
Nicole Schäfer
11.00 – 11.30 Coffee break and exhibition
Part 2: Workshops The workshops are intended for PhD students and junior researchers in the field. Registration is required and participants indicate two topics of their choice. The workshops take place at 11:30-12:30, and 12:45-13:45, and each topic is offered twice.
Methodology Topics: Complement methods in research & clinic
Workshop 1: COMPLEMENT DIAGNOSTICS
Zoltan Prohaszka - Room B005
Workshop 2: COMPLEMENT GENETICS (COMPLEMENT GENES, GENOTYPING OF COMMON SNPS, ANALYSIS OF “BIG DATA” FROM SEQUENCING)
Santiago Rodriguez de Cordoba - Room 007
Workshop 3: COMPLEMENT METHODS FOR THE RESEARCH LAB
Christoph Schmidt - Room B101
Workshop 4: ANIMAL MODELS IN COMPLEMENT RESEARCH
Jörg Köhl B008 5 METHODS INVOLVING COMPLEMENT AND IMMUNE CELLS
Christian Karsten Room - B102
Bench-to-bedside topics with a more clinical focus
Workshop 6: COMPLEMENT IN RENAL DISORDERS
Marina Noris - Room B201. Only at 12:45-13:45
Workshop 7: COMPLEMENT IN HEMOLYTIC DISORDERS
Sacha Zeerleder - Room B202. Only at 11:30-12:30
Workshop 8: COMPLEMENT IN CANCER
Lubka Roumenina - Room B301
Workshop 9: COMPLEMENT IN HUMAN DISEASE – THE CLINICIAN’S PERSPECTIVE
Marten Trendelenburg - Room B302
Workshop 10: COMPLEMENT IN TRANSPLANTATION, ISCHEMIC & THROMBOINFLAMMATORY CONDITIONS
Kristina Nilsson Ekdahl, Bo Nilsson - Room B306
13.45 – 14.45 Lunch
14.30 – 15.30 ICS Board Meeting - Room B005
Sunday, August 28, 2022 (07:30-15:55)
EMCHD Meeting followed by the conference dinner at 16:45
Keynote speech II
Introduction by Robert Rieben
Activation & Regulation
Infectious Diseases
Poster session:
Even abstract numbers 11:45 – 13:30
07.30 – 08.00 Coffee & croissants
08.00 – 09.30 SCIENTIFIC SESSION IV: THERAPEUTICS
Chairs: Christoph Schmidt, Christina Lamers
08.00 – 08.15 45 IN VIVO INHIBITION OF ALTERNATIVE PATHWAY ACTIVITY VIA MASP-3 INHIBITOR OMS906
Jason Cummings, Yi Li, Kathy Shaffer, Jeremy Freeman, Munehisa Yabuki, Thomas Dudler
08.15 – 08.30 169 A POTENT, TARGETED, ENZYME-LIKE INHIBITOR OF ALL THREE COMPLEMENT ACTIVATION PATHWAYS
Arthur Dopler, Sophia Lang, Amira Akilah, Markus Huber-Lang, Christoph Schmidt
08.30 – 08.45 130 THERAPEUTIC TARGETING OF FACTOR H TO INJURED TISSUES THROUGH LINKAGE WITH ANTI-C3D MAB DELIVERS POTENT AND DURABLE COMPLEMENT INHIBITION IN SKIN WITHOUT INHIBITING SYSTEMIC COMPLEMENT
Fei Liu, Sarah Ryan, Kelly Fahnoe, Jennifer Morgan, Purvi Mande, Shuyun Xu, Christine Lian, Katja Bieber, Enno Schmidt, Admar Verschoor, Ralf Ludwig, Joshua Thurman, Michael Holers, Shelia Violette, Stefan Wawersik
08.45 – 09.00 173 CHARACTERIZATION OF A NOVEL SMALL INTERFERING RNA FOR COMPLEMENT REGULATION THROUGH TARGETED SILENCING OF C3
Erik Richardson, Tara Barbour, Andrew Carvalho, Antoinette Hayes, Joshua Garlich, Kathrin Hultsch, Soham Mandal, Stephan Seiffert, Jochen Deckert, Anke Geick, Hans-Peter Vornlocher, David Eyerman, Lukas Scheibler
09.00 – 09.15 147 DESIGN AND EVALUATION OF C3 INHIBITORS OF THE COMPSTATIN FAMILY WITH PROLONGED TARGET RESIDENCE TIME
Christina Lamers, Hughes Sarah, Ranillo Resuello, John Lambris, Daniel Ricklin
09.15 – 09.30 126 PHARMACOKINETICS/PHARMACODYNAMICS OF KP104, A BIFUNCTIONAL ANTIBODY FUSION PROTEIN INHIBITOR OF COMPLEMENT, IN C5/FCRN-HUMANIZED TRANSGENIC MICE AND CYNOMOLGUS MONKEYS
Jay Ma, Xiang Gao, Takashi Miwa, Damodar Gullipalli, Sayaka Sato, Wenchao Song, Xihua Zhu, Jianjun Zhang, Chaomei He, Helen HFu, Richard Lee, Frederick Beddingfield, Wenru Song, Ping Tsui
09.30 – 10.00 Coffee break, Posters and Exhibition
10.00 – 10.45 KEYNOTE SPEECH II
Introduction by Robert Rieben
DECODING THE ROLES OF ENDOTHELIAL CELL HETEROGENEITY AND COMPLEMENT SYSTEM IN DISEASES AND REGENERATIVE MEDICINE BY SINGLE CELL AND SPATIALLY RESOLVED TRANSCRIPTOME ANALYSIS
Speaker: Prof. Yonglun Luo, Aarhus University, Denmark
10.45 – 11.45 SCIENTIFIC SESSION V: ACTIVATION & REGULATION
Chairs: Sacha Zeerleder, Mihaly Jozsi
10.45 – 11.00 181 GRANZYME K ELICITS A NEW PATHWAY FOR COMPLEMENT ACTIVATION
Carlos Donado, Helena Jonsson, Michael Brenner
11.00 – 11.15 70 THE CONTRIBUTION OF THE ALTERNATIVE PATHWAY TO COMPLEMENT ACTIVATION DEPENDS ON THE STRENGTH OF CLASSICAL PATHWAY INITIATION
Esther de Boer, Astrid Thielen, Jeroen Langereis, Angela Kamp, Mieke Brouwer, Nienke Oskam, Marlieke Jongsma, Robbert Spaapen, Sacha Zeerleder, Richard Pouw, Gestur Vidarsson, Theo Rispens, Diana Wouters, Ilse Jongerius
11.15 – 11.30 151 MOLECULAR CONDITIONS FOR THE ASSEMBLY OF INITIAL C3 AP CONVERTASES FORMED BY NATIVE C3 AT BIOMATERIAL SURFACES
Anna Adler, Vivek Anand Manivel, Kristina Nilsson Ekdahl Nilsson Bo, Karin Fromell
11.30 – 11.45 162 QUANTIFICATION OF THE ZYMOGENICITY AND THE SUBSTRATEINDUCED ACTIVITY ENHANCEMENT OF COMPLEMENT FACTOR D Ráhel Dani, Gábor Oroszlán, Róbert Martinusz, Bernadett Dobos, Evelin Vadas, Péter Závodszky, Péter Gál, József Dobó
11.45 – 13.30 POSTER VIEWING SESSION II
All topics: even poster numbers. Posters will be displayed during the whole congress
12.00 – 13.30 Standing Lunch, Posters and Exhibition
13.30 – 15.00 SCIENTIFIC SESSION VI: INFECTIOUS DISEASES
Chairs: Reinhard Würzner, Suzan Rooijakkers
13.30 – 13.45 111 RECOGNITION AND INHIBITION OF SARS-COV-2 BY HUMORAL INNATE IMMUNITY PATTERN RECOGNITION MOLECULES
Cecilia Garlanda, Matteo Stravalaci, Isabel Pagani, Elvezia Maria Paraboschi, Sarah Mapelli, Andrea Cavalli, Barbara Bottazzi, Francesco Scavello, Nicasio Mancini, Milos Matkovic, Peter Garred, Rosanna Asselta, Elisa Vicenzi, Alberto Mantovani
13.45 – 14.00 144 AUTOANTIBODIES AND COMPLEMENT ACTIVATION IN BRONCHOALVEOLAR LAVAGE AND TISSUES OF COVID-19 PATIENTS
Paolo Macor, Luca De Maso, Stefano Di Bella, Paolo Durigutto, Marcello Manfredi, Erik Roman-Pognuz, Verena Zerbato, Stella Bernardi, Rossana Bussani, Roberto Luzzati, PierLuigi Meroni, Francesco Tedesco
14.00 – 14.15 109 HIV-1 TRANS INFECTION VIA TNTS IS IMPEDED BY TARGETING C5AR
Giulia Bertacchi, Doris Wilflingseder
14.15 – 14.30 92 PROMOTING FC-FC INTERACTIONS BETWEEN ANTI-CAPSULAR ANTIBODIES PROVIDES STRONG IMMUNE PROTECTION AGAINST STREPTOCOCCUS PNEUMONIAE Leire Aguinagalde Salazar, Maurits den Boer, Suzanne Castenmiller, Seline Zwarthoff, Carla Gosselaar-de Haas, Piet Aerts, Frank Beurskens, Janine Schuurman, Albert Heck, Kok van Kessel, Suzan Rooijakkers
14.30 – 14.45 21 COMPLEMENT MEDIATED KILLING OF KLEBSIELLA PNEUMONIAE IS AFFECTED BY COLISTIN RESISTANCE MUTATIONS
Sjors van der Lans, Axel Janssen, Dennis Doorduijn, Willem van Schaik, Bart Bardoel, Suzan Rooijakkers
14.45 – 15.00 110 FLICK THE SWITCH – SUBCLASS SWITCHING GENERATES A COMPLEMENT-FIXING MONOCLONAL ANTIBODY THAT INHIBITS MALARIA TRANSMISSION
Maartje Inklaar, Roos de Jong, Ezra Bekkering, Rianne Stoter, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Nicholas Proellochs, Matthijs Jore
15.00 – 15.40 HANS MÜLLER EBERHARD PLAQUE, SVAR AWARDS & ECN MEDALS
15.40 – 16.30 Coffee break, Posters, Exhibition, Networking
16.45 Bus departure to Lucerne from vonRoll campus
19.00 – 22.00 Boarding for the Conference Dinner on the lake of Lucerne, Pier 6
22.00 – 24.00 Bus transfer from Lake Lucerne to Bern
Saturday, August 27, 2022 (07:30-17:30)
EMCHD Meeting
Keynote speech I
Prof. Christian Heinis, Swiss Federal Institute of Technology, Lausanne
Sessions:
Structure & Function
Crosstalk & Noncanonical Functions
Autoimmune Disease
Poster session:
Odd abstract numbers 11:00 – 12:30
07.30 – 08.00 Coffee & croissants
08.00 – 08.15 WELCOME ADDRESSRobert Rieben and Reinhard Würzner
08.15 – 09.45 SCIENTIFIC SESSION I: STRUCTURE & FUNCTION
Chairs: Nicole Thielens, Richard Pouw
08.15 – 08.30 10 HIGH-RESOLUTION IMAGING OF COMPLEMENT MOLECULES ON GRAM-NEGATIVE BACTERIA
Dani Heesterbeek, Johannes Schneider, Kok van Kessel Dennis, Doorduijn, Bart Bardoel, Jos van Strijp, Marek Basler, Suzan Rooijakkers
08.30 – 08.45 75 STRUCTURAL INSIGHTS INTO THE HEXAMERIC FORM OF THE IGM FC-CORE DOMAIN AND ITS BINDING CHARACTERIZATION TO C1Q
Andrea J. Pinto, Leandro Estrozi, Isabelle Bally, Anne Chouquet, Véronique Rossi, Guy Schoehn, Nicole Thielens, Christine Gaboriaud, Wai Li Ling, Jean-Baptiste Reiser
08.45 – 09.00 54 FUNCTIONAL CONSEQUENCES OF MISSENSE MUTATIONS AT POSITION 263 IN COMPLEMENT C2 PROTEIN
Alicja Kuźniewska, Marcel Thiel, Daria Kowalska, Stanisław Ołdziej, Emilia Ajrona, Santiago Rodriguez de Córdoba, Marcin Okrój, Aleksandra Urban
09.00 – 09.15 119 RECOGNITION OF POST-TRANSLATIONAL LYSINE MODIFICATIONS BY THE LECTIN PATHWAY INITIATOR FICOLIN 3
Linnea Lindelöf, David Eikrem, Kristina Nilsson Ekdahl, Peter Garred, Bo Nilsson, Oskar Eriksson
09.15 – 09.30 183 MODULATION OF THE CLASSICAL COMPLEMENT PATHWAY BY FACTOR H-RELATED PROTEINS
Hani Hashim Hammad, Alexandra Papp, Ádám I. Csincsi, Barbara Uzonyi, Anna Blom, Józsi Mihály
09.30 – 09.45 116 CRYSTAL STRUCTURE OF THE FACTOR H DOMAINS 8-14 UNCOVERS THE SIGNIFICANCE OF THE CENTRAL DOMAINS FOR THE DISCRIMINATION BETWEEN SELF AND NONSELF BY FACTOR H
Christoph Schmidt, Arthur Dopler, Dierk Niessing, Thomas Monecke
09.45 – 10.15 Coffee break, Posters and Exhibition
10.15 – 11.00 KEYNOTE SPEECH I
Introduction by Sacha Zeerleder
DEVELOPMENT OF CYCLIC PEPTIDE INHIBITORS OF FXII AND OTHER PLASMA PROTEASES BY PHAGE DISPLAY
Prof. Christian Heinis, Swiss Federal Institute of Technology, Lausanne
11.00 – 12.30 POSTER VIEWING SESSION I
All topics: odd poster numbers. Posters will be displayed during the whole congress
12.30 – 14.00 Standing lunch, Exhibition
13.00 – 13.40 CSL BEHRING SYMPOSIUM
Introduction by Rolf Spirig
TARGETING COMPLEMENT AND OTHER PATHWAYS IN KIDNEY ISCHEMIA-REPERFUSION INJURY
Prof. Peter Cowan, St. Vincent’s Hospital, Melbourne
13.00 – 14.00 ECN Board Meeting Room B005, Building Fab8
14.00 – 16.30 SCIENTIFIC SESSION II: CROSSTALK & NONCANONICAL FUNCTIONS
Chairs: Lubka Roumenina, Verena Schroeder
14.00 – 14.15 49 ISOFORM-SPECIFIC BINDING OF APOLIPOPROTEIN E TO COMPLEMENT FACTOR H ALTERS AMYLOID-Β-MEDIATED NEUROTOXICITY IN VITRO AND IN VIVO
Larisa Chernyaeva, Giorgio Ratti, Laura Teirilä, Uni Rankka, Satoshi Fudo, Anssi Pelkonen, Paula Korhonen, Katarzyna Leskinen, Salla Keskitalo, Kari Salokas, Christina Christodoulopoulou, Katrina Crompton, Markku Varjosalo, Tarja Malm, Ville Leinonen, Angelika Chroni, Päivi Saavalainen, Seppo Meri, Adam Wollman, Eija Nissilä, Karita Haapasalo
14.15 – 14.30 76 COMPLEMENT AND HAEMOSTASIS: EFFECTS OF COMPLEMENT INHIBITORS IN A MICROFLUIDIC BLEEDING MODEL
Murielle Golomingi, Jessie Kohler, Christin Lamers, Richard Pouw, Daniel Ricklin, Elaissa Trybus Hardy, Wilbur Lam, Verena Schroeder
14.30 – 14.45 112 IN HUMAN MICROVASCULAR ENDOTHELIAL CELLS (HMEC-1) C5A/C5AR1 INDUCES VON WILLEBRAND FACTOR (VWF) RELEASE FROM WEIBEL-PALADE BODIES (WPBS) VIA ADENYLYL-CYCLASE ACTIVATION
Sistiana Aiello, Sara Gastoldi, Miriam Galbusera, Ariela Benigni, Giuseppe Remuzzi, Marina Noris
14.45 – 15.00 43 CELL-INTRINSIC C3 MEDIATES PANCREATIC BETA-CELL SURVIVAL IN INFLAMMATORY AND CELL STRESS CONDITIONS
Ben King, Klaudia Kulak, Marina Mackay, Lucie Colineau, Anna Blom
15.00 – 15.15 82 ALTERNATIVE SPLICING ENCODES INTRACELLULAR CD59 ISOFORMS WHICH MEDIATE INSULIN SECRETION, ARE DOWNREGULATED IN DIABETES, AND INTERACT WITH DNA, SUGGESTING INVOLVEMENT IN GENE TRANSCRIPTION REGULATION
Ewelina Golec, Alexander Ekstrom, Maciej Noga, Muhmmad Omar Hmeadi, Per-Eric Lund, Bruno Villoutreix, Ulrika Krus, Katarzyna Wozniak, Olle Korsgren, Erik Renström, Sebastian Barg, Ben King, Anna Blom
15.15 – 15.30 101 ANAPHYLATOXIN RECEPTORS REGULATE THE DIFFERENTIATION AND FUNCTION OF DENDRITIC CELLS SUBSETS FROM BONE MARROW-DERIVED PRECURSORS
Alicja Anna Nowacka, Sven Geisler, Chandrashekhar Pasare, Jörg Köhl
15.30 – 16.00 Coffee break
16.00 – 16.45 CURRENT TOPICS I: COVID-19
Speaker: Michael Osthoff
Moderator: Marten Trendelenburg
16.45 – 17.30 SCIENTIFIC SESSION III: AUTOIMMUNE DISEASE
Chairs: Marten Trendelenburg, Anna Blom
16.45 – 17.00 29 POST-TRANSLATIONALLY MODIFIED PROTEINS BIND AND ACTIVATE COMPLEMENT LEADING TO INCREASED CELLULAR BINDING AND UPTAKE
Michelle van den Beukel, Stef van der Meulen, Lu Zhang, Nicole Borggreven, George Janssen, Peter van Veelen, Leendert Trouw
17.00 – 17.15 86 C5AR2 DEFICIENCY AMELIORATES INFLAMMATION IN MURINE EPIDERMOLYSIS BULLOSA ACQUISITA BY REGULATING C5A- AND FCΓR-MEDIATED FUNCTIONS OF NEUTROPHILS
Daniel Seiler, Marie Kleingarn, Katja Kähler, Tilo Freiwald, Jack Bibby, Caroline Gruner, Jovan Schanzenbacher, Elvira Ehlers-Jeske, Samyr Kenno, Christian Sadik, Enno Schmidt, Katja Bieber, Behdad Afzali, Jörg Köhl, Ralf Ludwig, Claudia Kemper, Christian Karsten
17.15 – 17.30 124 A COMPLEMENT C3-NANOBODY INHIBITS THE AP CONVERTASE STABILIZATION MEDIATED BY ANTI-C3BBB AUTOANTIBODIES IN C3 GLOMERULOPATHY
Julia Roquigny, Veronique Frémeaux-Bacchi, Gregers Andersen, Lubka Roumenina, Seppo Meri, Marion Mandavit, Sophie Chauvet, Marie-Agnès Dragon-Durey
19.00 – 22.00 LOC, Chair & Board Dinner, Distelzwangkeller, Gerechtigkeitsgasse 79, 3011 Bern
Monday, August 29, 2022 (08:30-14:00)
EMCHD Meeting
Sessions:
Neurological & non-infectious Diseases
Thromboinflammation
Renal Diseases
07.30 – 08.00 Coffee & croissants
08.00 – 09.00 SCIENTIFIC SESSION VII: NEUROLOGICAL & NON-INFECTIOUS DISEASES
Chairs: Diana Pauly, Jörg Köhl
08.00 – 08.15 5 COMPLEMENT RECEPTOR 1 IS EXPRESSED ON BRAIN CELLS AND IMPACTS ROLES OF MICROGLIAL RELEVANT TO ALZHEIMER’S DISEASE
Nikoleta Daskoulidou, Bethany Shaw, Megan Torvell, Sarah Carpanini, Paul Morgan
08.15 – 08.30 6 TERMINAL COMPLEMENT PATHWAY ACTIVATION DRIVES SYNAPTIC LOSS IN ALZHEIMER’S DISEASE MODELS
Sarah Carpanini, Megan Torvell, Ryan Bevan, Robert Byrne, Nikoleta Daskoulidou, Takashi Saito, Takaomi Saido, Philip Taylor, Timothy Hughes, Wioleta Zelek, Paul Morgan
08.30 – 08.45 100 10 YEARS FOLLOW-UP OF CD59 CONGENITAL DEFICIENCY: NEUROINFLAMMATION, HEMOLYSIS, ECULIZUMAB, RAVULIZUMAB AND POZELIMAB
Dror Mevorach, Netanel Karbian, Marian Zeibak, Itamar Altman
08.45 – 09.00 9 MICE WITH HYPER FUNCTIONAL COMPLEMENT DEVELOP AGERELATED NON-ALCOHOLIC STEATOHEPATITIS
Beth Gibson, Isabel Pappworth, Harriet Denton, Ola Kamala, Fiona Oakley, Alastair Burt, Kevin Marchbank
09.00 – 10.00 SCIENTIFIC SESSION VIII: THROMBOINFLAMMATION
Chairs: Robert Rieben, Felix Poppelaars
09.00 – 09.15 166 INFLAMMATORY STIMULI REVEAL A DIFFERENTIAL GLYCOCALYX RESPONSE BETWEEN VENOUS AND ARTERIAL ENDOTHELIAL CELLS LEADING TO DIFFERENCES IN COMPLEMENT DEPOSITION
Anastasia Milusev, Michelle Staudenmann, Alain Despont, Jianfang Ren, Robert Rieben, Nicoletta Sorvillo
09.15 – 09.30 165 ACTIVATION OF THE LECTIN PATHWAY OF COMPLEMENT SYSTEM AFTER ISCHEMIC STROKE IN A HUMANIZED MOUSE MODEL EXPRESSING HUMAN MANNOSE-BINDING LECTIN
Stefano Fumagalli, Domenico Mercurio, Alessia Valente, Serena Seminara, Gizem Erol, Gregory Stahl, Maria-Grazia De Simoni, Gianluigi Forloni, Luana Fioriti, Franca Orsini
09.30 – 09.45 2 AIR EMBOLI TRIGGER A COMPLEMENT C3-DEPENDENT THROMBOINFLAMMATION IN HUMAN WHOLE BLOOD AND PIGS
Benjamin Stage Storm, Judith Ludviksen, Dorte Christiansen, Hilde Fure, Pettersen Kristin, Anne Landsem, Bent Aksel Nielsen, Knut Dybwik, Corinna Lau, John Lambris, Tonje Braaten, Nielsen Erik Waage, Tom Eirik Mollnes
09.45 – 10.00 78 MODULATION OF THE COMPLEMENT TERMINAL PATHWAY AMELIORATES PERITONEAL INJURIES IN A RAT PERITONEAL DIALYSIS MODEL
Masashi Mizuno, Naoki Kamegai, Hangsoo Kim, Paul Morgan, Yasuhiro Suzuki, Sosuke Fukui, Hiroshi Kojima, Wioleta Zelek
10.00 – 10.30 Coffee Break, Posters and Exhibition
10.30 – 12.00 SCIENTIFIC SESSION IX: RENAL DISEASES
Chairs: Kevin Marchbank, Elena Goicoechea de Jorge
10.30 – 10.45 121 PROPERDIN DEFICIENCY IS PROTECTIVE IN THE C3 GOF MOUSE MODEL OF AHUS
Ola Kamala, Kate Smith-Jackson, Harriet Denton, Tom Cox, Isabel Pappworth, David Kavanagh, Kevin Marchbank
10.45 – 11.00 97 FUNCTIONAL CHARACTERIZATION OF AHUS-ASSOCIATED GENETIC VARIANTS IN THE SERINE PROTEASE DOMAIN OF FACTOR B SUGGESTS A NOVEL MECHANISM TO ENHANCE COMPLEMENT ACTIVATION
Héctor Martín Merinero, Yuzhou Zhang, Emilia Arjona Bolaños, Renee Goodfellow, Gonzalo Ligero, Elena Gomez Rubio, Sonsoles Martín Santamaría, Richard Smith, Santiago Rodríguez de Córdoba
11.00 – 11.15 74 HUMAN COMPLEMENT C3 GAIN-OF-FUNCTION VARIANT IS RESISTANT TO COFACTOR ACTIVITY LEADING TO EXCESSIVE COMPLEMENT ACTIVATION AND RENAL DISEASE
Xiaobo Wu, Zheng Hu, Bryn Webb, Dusan Bogunovic, Bruce Gelb, Dennis Hourcade, John Atkinson
11.15 – 11.30 64 C7 BUT NOT C5AR IS ESSENTIAL TO THE DEVELOPMENT OF ATYPICAL HAEMOLYTIC URAEMIC SYNDROME IN THE C3 GAIN-OFFUNCTION MODEL
Kate Smith-Jackson, Patrick Walsh, Ola Kamala, Charlotte Cox, Isabel Pappworth, David Kavanagh, Kevin Marchbank
11.30 – 11.45 115 COPY NUMBER AND SEQUENCE VARIATIONS IN THE FHR1 GENE INFLUENCE COMPLEMENT REGULATION AND COOPERATION WITH COMPLEMENT REGULATORS
Luce Perie, Selina Stippa, Andrea Hartmann, Michael Mihlan, Thorsten Wiech, Peter Zipfel
11.45 – 12.00 178 DETECTION OF RENAL C3D DEPOSITION AS A MARKER OF DISEASE ACTIVITY IN LUPUS NEPHRITIS
Felix Poppelaars, Brandon Renner, Jennifer Laskowski, Andrew Feemster, Liudmila Kulik, Michael Holers, Joshua Thurman
12.00 – 12.15 Short Break
12.15 – 13.00 CURRENT TOPICS II - FUTURE OF COMPLEMENT ON THERAPEUTICS
Speaker: Daniel Ricklin Moderator: Richard Harrison
13.00 – 13.10 ECN GENERAL ASSEMBLY
13.10 – 13.30 Introduction of the next meetings – ICS President, Congress chairpersons of 29th ICW in 2023
19th EMCHD in 2024
13.30 – 14.00 TRAVEL AWARDS, POSTER PRESENTATION PRIZES
Moderator: Robert Rieben & Reinhard Würzner
14.00 CLOSING CEREMONY– FAREWELL – END OF EMCHD 2022
14.15 – 15.00 Lunch (Lunch bag)
14.30 – 15.55 ECN Board Meeting B005, Fab8
14.30 – 15.55 Offered by the CORVOS Program Lecture: “How to make a poster” – Auditorium 001, Fab6
Kali Tal, University of Bern